Term Overlap P-value Adjusted P-value Old P-value Old Adjusted P-value Odds Ratio Combined Score Genes Neural Crest Differentiation WP2074 67/101 1.2335092685092921E-20 2.0599604784105178E-18 0 0 6.743352941176471 309.1276977519317 FGF2;ETS1;CDH7;CDH6;DMBX1;FGF8;CDH2;MPZ;MYB;HEY2;ZIC1;HOXA1;SOX9;FOXD3;MSX2;OLIG3;MSX3;PAX3;OLIG1;AXIN2;OLIG2;ISL1;SOX10;COL2A1;DCT;PAX7;HAND1;HOXB1;NOTCH3;HDAC2;NOTCH1;DLX5;COL11A2;WNT8A;TWIST1;ASCL1;DLL1;DLL3;HDAC7;DLL4;PRTG;GBX2;MBP;WNT1;HES5;TFAP2A;TFAP2B;FZD3;WNT3A;BMP7;NFKB1;PHOX2B;GFAP;NFKB2;FGF15;LHX2;TLX2;LHX1;ID1;SNAI1;PMP22;SNAI2;LHX5;FGFR3;NEUROG1;FGFR2;FGFR1 Calcium Regulation in the Cardiac Cell WP553 78/147 1.4439683672508477E-15 1.2057135866544578E-13 0 0 3.869013143239029 132.20952322150265 CHRM2;RYR1;CHRM3;RYR2;CHRM1;CHRM4;ADRA1D;ARRB1;ADRA1B;ADRA1A;SLC8A1;RGS2;RGS3;GJA3;GJA4;RGS9;RGS6;CDK5RAP2;RGS7;PRKCH;PRKCB;PRKCE;PRKCD;PRKCA;ATP1B2;CACNB1;GJD2;CACNB3;ADCY9;PRKAR1B;PRKD1;CAMK2B;GNAZ;RGS17;CAMK2D;RGS19;RGS14;RGS16;CAMK2A;CACNA1B;ATP1A4;CACNA1A;ITPR2;ADCY3;CACNA1D;ADRB1;ADCY2;CACNA1C;ADCY1;ADCY8;PRKCZ;CACNA1E;ADCY7;ADCY6;GNAI1;ADCY5;GJC2;PRKAR2B;GNG4;PRKAR2A;GNG7;GNA11;GNG8;RGS20;CACNA1S;KCNJ3;KCNJ5;KCNB1;ATP2B2;GNG12;GNAO1;SLC8A3;PKIB;GJB2;CAMK4;GNAS;RGS10;RGS11 Non-odorant GPCRs WP1396 116/267 4.824113630010051E-14 2.6854232540389286E-12 0 0 2.637567865544018 80.87459424022028 NPFFR2;CHRM2;CHRM3;VIPR1;OXTR;VIPR2;CHRM1;GPR68;CHRM4;NPY2R;HTR4;CELSR1;CELSR2;CELSR3;RXFP3;HTR6;HTR7;ADORA1;GHSR;CASR;LHCGR;SMO;PTGFR;ADCYAP1R1;C5AR2;LPAR3;ADRB1;MCHR1;CRHR1;CRHR2;HRH1;CALCR;HRH3;GALR2;HRH2;TBXA2R;GALR1;NPBWR1;DRD2;NTSR1;CCR10;DRD4;NTSR2;DRD5;FZD1;FZD3;FZD2;FZD4;HTR1F;FZD6;HTR1D;FZD9;HTR1A;FZD8;HTR1B;NMBR;GLP1R;ADRA1D;PTH1R;ADRA1B;ADRA1A;GRM1;MC4R;GRM3;GRM2;GRM5;GRM4;GRM7;GRM6;GRM8;FFAR4;PRLHR;FFAR2;QRFPR;NPY5R;TACR3;PTH2R;AVPR1A;TACR1;SSTR1;ADRA2C;ADRA2B;AGTR1A;ADRA2A;SSTR4;SSTR5;GPRC5B;CCKBR;ADORA2A;ADORA2B;OPRD1;PTGER4;PTGER1;PTGER2;PTGER3;CXCR4;PROKR1;PROKR2;P2RY6;CNR1;P2RY2;P2RY1;KISS1R;S1PR1;S1PR3;S1PR5;GABBR2;GCGR;SCTR;GPR50;GPR6;HTR5A;HTR5B;TSHR;HCRTR2;HCRTR1 ESC Pluripotency Pathways WP339 61/118 7.581562243642674E-12 3.1653022367208163E-10 0 0 3.6518014966399575 93.50547956941881 WNT2B;PIK3CD;FGF2;FGF3;FGF5;FGF8;FGF9;MYC;AKT1;JAK1;PDGFRA;WNT5B;WNT5A;NOG;GAB1;WNT9B;FOS;WNT16;PDGFB;LRP5;PDGFA;EGFR;WNT6;WNT11;MAPK7;FGF20;WNT1;FGF23;WNT2;WNT3;MAPK4;FGF21;MAP2K6;WNT4;FZD1;WNT10B;WNT10A;FZD3;SMAD4;JUN;FZD2;FZD4;WNT3A;WNT7B;FZD6;FZD9;FZD8;SMAD9;WNT7A;SMAD6;MAPK12;FGF15;FGF14;FGF18;FGFR4;FGFR3;FGF12;FGFR2;FGF11;FGFR1;FGF10 Wnt Signaling Pathway WP403 37/60 1.2570138881673491E-10 4.198426386478946E-9 0 0 5.472406181015453 124.75505635395949 WNT2B;FZD10;PRKCZ;WNT6;FRAT1;CCND2;WNT11;CCND1;PLAU;MYC;WNT1;WNT2;WNT3;WNT4;FZD1;WNT10B;JUN;WNT10A;FZD3;PRKCH;FZD2;WNT5B;PRKCB;WNT3A;PRKCE;WNT7B;WNT5A;PRKCD;FZD6;FZD9;FZD8;WNT7A;PRKCA;WNT16;FOSL1;SFRP4;PRKD1 Monoamine GPCRs WP570 25/33 1.6962662493770652E-10 4.721274394099498E-9 0 0 10.612753192426243 238.75958097768807 CHRM2;CHRM3;CHRM1;CHRM4;ADRB1;ADRA1D;ADRA1B;HTR4;ADRA1A;HTR6;HRH1;HTR7;HRH2;DRD2;DRD4;DRD5;HTR1F;HTR1D;HTR1A;HTR1B;ADRA2C;HTR5A;HTR5B;ADRA2B;ADRA2A Myometrial Relaxation and Contraction Pathways WP385 69/153 8.934755668737721E-10 2.1315774238274277E-8 0 0 2.8030473861398715 58.404020995277676 RYR1;RYR2;OXTR;ADM;OXT;ARRB1;SLC8A1;RGS2;RGS3;RGS9;RGS6;CDK5RAP2;RGS7;PRKCH;IGFBP5;IGFBP4;PRKCB;GSTO1;IGFBP3;PRKCE;PDE4D;PRKCD;PRKCA;FOS;MYL4;ACTA1;CACNB3;ADCY9;PRKAR1B;CRH;PRKD1;ATF3;CAMK2B;RGS17;RAMP2;CAMK2D;RGS19;RGS14;RGS16;CAMK2A;ITPR2;ADCY3;ADCY2;ADCY1;ADCY8;PRKCZ;ADCY7;CRHR1;ADCY6;ADCY5;CNN1;PRKAR2B;GNG4;PRKAR2A;GNG7;PLCG2;GNG8;RGS20;IGFBP6;CORIN;JUN;GNG12;NFKB1;PKIB;GNAS;RGS10;RGS11;RAMP1;PLCD1 Heart Development WP2067 29/44 1.3153815290568574E-9 2.7458589419061897E-8 0 0 6.568561774643749 134.3214332670873 FOXC2;FOXC1;NOTCH1;SRF;GATA6;GATA4;SHH;FGF8;HEY1;ERBB3;HEY2;TBX20;PITX2;NKX2-5;MEF2C;SMAD4;IRX4;NFATC2;NFATC1;TBX5;ISL1;TBX2;VEGFA;BMP2;HAND2;HAND1;BHLHE40;FGF10;FOXA2 Endochondral Ossification WP1270 36/62 2.370565425132064E-9 4.3987158444117195E-8 0 0 4.70818124713512 93.50512616263927 CDKN1C;IHH;PTH1R;FGF2;GLI3;PTHLH;IGF1R;GHR;ADAMTS5;ACAN;CHST11;PLAU;ADAMTS1;FRZB;SERPINH1;AKT1;TIMP3;ENPP1;SOX9;SOX6;NKX3-2;STAT5B;MEF2C;TGFB2;TGFB1;IGF2;MMP9;RUNX3;BMP7;RUNX2;BMP6;VEGFA;COL2A1;FGF18;FGFR3;FGFR1 Dopaminergic Neurogenesis WP1498 22/30 6.146463756000603E-9 1.0264594472521006E-7 0 0 9.333058305830583 176.4637631969663 RET;CDKN1C;TGFB1;EN2;EN1;ASCL1;SLC6A3;NEUROD1;NR4A2;SHH;FGF8;GBX2;LMX1A;MSX1;LMX1B;WNT1;NKX6-1;SLC18A2;NEUROG2;NKX2-2;PITX3;FOXA2 Adipogenesis genes WP447 60/134 1.5170938158439575E-8 2.3032242476903717E-7 0 0 2.7630892485563 49.74633887215171 IRS1;RORA;IRS3;LIPE;CYP26B1;MEF2A;NCOA1;TLE3;MEF2C;MEF2B;PTGIS;WNT5B;EBF1;PRLR;SFRP4;PPARG;PLIN1;PPARA;FOXC2;CEBPA;CEBPB;CEBPD;EPAS1;UCP1;LPL;TWIST1;GATA4;GATA3;GATA2;SOCS1;RXRA;FRZB;LMNA;NRIP1;NDN;SPOCK1;WNT1;RXRG;MEF2D;FZD1;GDF10;STAT5B;WNT10B;EGR2;TGFB1;SMAD3;GADD45B;NR2F1;OSM;NSG1;DLK1;BMP3;CYP26A1;BMP2;BMP1;LEP;PNPLA3;ID3;LPIN2;MIXL1 Wnt Signaling Pathway and Pluripotency WP723 47/97 2.7020714739067953E-8 3.7603828011869566E-7 0 0 3.1991194690265488 55.74997385243045 WNT2B;LEF1;LRP5;PRKCZ;NKD1;NKD2;WNT6;FRAT1;CCND2;WNT11;CCND1;PLAU;MYC;WNT1;WNT2;WNT3;WNT4;FZD1;WNT10B;FOXD3;WNT10A;FZD3;JUN;PRKCH;FZD2;WNT5B;PRKCB;FZD4;WNT3A;PRKCE;WNT7B;WNT5A;PRKCD;FZD6;FZD9;WNT9B;FZD8;WNT7A;PRKCA;HNF1B;AXIN2;WNT16;FOSL1;PPP2R2C;PPP2R2B;PRKD1;CD44 Wnt Signaling in Kidney Disease WP3857 24/37 5.6398267016467686E-8 7.24500814750008E-7 0 0 6.266276096784571 104.58933280709796 FZD1;WNT10B;WNT10A;FZD3;WNT2B;FZD2;WNT5B;FZD4;WNT3A;WNT7B;FZD6;WNT5A;LRP5;FZD9;WNT9B;FZD8;WNT7A;WNT16;WNT6;WNT11;WNT1;WNT2;WNT3;WNT4 Wnt Signaling Pathway NetPath WP539 48/108 5.288765719184891E-7 6.308741965027692E-6 0 0 2.7214870546581102 39.33232092899297 CAMK2B;CAMK2D;LEF1;CAMK2A;FHL2;LRP5;ARRB1;CXXC4;NKD1;FRAT1;FRAT2;SOX1;CCND1;MYB;AKT1;SOX9;WNT1;WNT2;WNT3;WNT4;TFAP2A;FZD1;SMAD4;JUN;SMAD3;FZD2;PRKCB;FZD4;WNT3A;WNT5A;FZD6;FZD9;FZD8;WNT7A;PRKCA;AXIN2;DKK1;RUNX2;PAX2;HIPK2;NR5A1;SFRP1;DAB2;SFRP2;DLG2;DLG4;MAP1B;ROR2 SIDS Susceptibility Pathways WP1266 31/61 1.6822075421070514E-6 1.8728577302125173E-5 0 0 3.508913874191652 46.65242620396668 RET;RYR2;VIPR1;ADCYAP1R1;VIPR2;CHRNA4;RORA;IL6RA;GATA3;ASCL1;GATA2;SLC6A4;SCN5A;HES5;NKX3-1;NKX2-2;CHRNB2;KCNH2;HTR1A;EN1;POU3F2;PHOX2B;NFKB1;PHOX2A;ADCYAP1;REST;TLX3;KCNQ1;FEV;LMX1B;AVP GPCRs, Class C Metabotropic glutamate, pheromone WP327 12/15 4.458362389409075E-6 4.6534157439457215E-5 0 0 13.549945115257959 166.9452022261785 GRM3;GABBR2;GRM2;CASR;GRM5;GPRC5B;GRM4;GRM7;GRM6;GRM8;GPRC5C;GRM1 Focal Adhesion-PI3K-Akt-mTOR-signaling pathway WP2841 108/324 8.860835323700541E-6 8.704467641517591E-5 0 0 1.706324287956941 19.851154120570754 FOXA1;CHRM2;CHRM1;CSF1;IRS1;ITGA2B;TNC;IRS3;FGF2;FGF3;IGF1R;COMP;LIPE;FGF8;FGF9;CREB3L1;KDR;AKT1;PDGFRA;PRLR;PGF;COL4A2;COL4A1;DDIT4;PFKFB3;EPAS1;PDGFB;IL4RA;PDGFA;LPAR3;FOXO3;EFNA5;PIK3R5;VTN;FGF20;FGF21;NGFR;INSR;GNG12;COL1A1;EFNA1;EFNA3;FGF15;COL1A2;EFNA2;FGF14;COL5A1;KITL;ITGA11;FGF18;FGFR4;FGFR3;FGF12;FGFR2;FGF11;FGFR1;FGF10;CDKN1A;CDKN1B;FLT1;ITGB5;LAMC3;ITGB4;FLT4;ITGB3;PIK3CD;LAMC2;PIK3C2A;PIK3CG;PIK3C2B;GHR;ITGB8;ITGB6;JAK2;JAK3;JAK1;ITGA4;ITGA2;OSMR;NGF;TBC1D1;COL2A1;COL6A2;ITGA7;MET;PHLPP1;TNXB;PRKAA2;LAMA4;COL11A2;LAMA3;IL6RA;THBS2;THBS1;EGFR;THBS4;RELN;GNG4;GNG7;GNG8;EIF4E;NOS2;OSM;LAMB1;EPOR;VEGFA;PPP2R2C;PPP2R2B BMP Signaling Pathway in Eyelid Development WP3663 14/20 9.57866387951569E-6 8.886871488217336E-5 0 0 7.9060692583644485 91.36231850177516 FOXC2;JUN;FOXC1;SMAD4;NOTCH1;TGFA;INHBB;DKK2;EGFR;SFRP1;SHH;PITX2;FGFR2;FGF10 Primary Focal Segmental Glomerulosclerosis FSGS WP2573 33/72 1.3798580556769771E-5 1.2128226068318693E-4 0 0 2.872891995521021 32.15037582240319 CDKN1C;CAMK2B;CDKN1A;CDKN1B;NOTCH1;CD151;ITGB4;CD80;ITGB3;PTPRO;LRP5;CLDN1;VTN;CDH2;PODXL;AKT1;SYNPO;CDK5RAP2;KIRREL3;TRPC6;TGFB1;JAG1;KRT8;PARVA;DKK1;DNM1;PAX2;INF2;WT1;NPHS2;FAT1;IRF6;LMX1B G Protein Signaling Pathways WP232 39/92 2.3034086634340665E-5 1.9233462339674455E-4 0 0 2.499416627775185 26.690108967974506 GNAZ;PDE1B;AKAP7;ADCY3;ADCY2;ADCY1;ADCY8;ADCY7;PRKCZ;ADCY6;GNAI1;ADCY5;GNA14;PPP3CC;GNG4;PRKAR2B;GNG7;GNA11;PRKAR2A;PDE4A;GNG8;PDE8B;PDE8A;KCNJ3;PRKCH;PRKCB;PDE4D;PRKCE;PDE4C;PRKCD;PRKCA;GNG12;GNAO1;ADCY9;GNAL;PRKAR1B;PRKD3;GNAS;PRKD1 Hypothetical Network for Drug Addiction WP1246 18/31 2.476165740562732E-5 1.9691413270189347E-4 0 0 4.693508294299677 49.78035419467687 CAMK2B;GRIA2;ZHX2;PRKCE;ADCY1;ADCY8;GRIN2C;GRIN2B;GRM1;GRIN2D;GRIN1;ACTA1;GRM5;GRIN2A;CAMK4;DRD2;DRD4;GRIA4 Ovarian Infertility Genes WP273 17/31 1.1150210354910032E-4 8.464023314863524E-4 0 0 4.114960753532182 37.45217992154075 EGR1;CEBPB;LHCGR;CDKN1B;SMAD3;VDR;PTGER2;PRLR;SYNE2;ESR2;NR5A1;DAZL;CCND2;GJA4;NRIP1;PGR;INHA Spinal Cord Injury WP2432 39/99 1.582584692721847E-4 0.0011490941029762977 0 0 2.2068131625441696 19.312442055928553 RTN4R;NCAN;PLA2G5;KLK8;NTN1;TNFSF13B;EFNB2;ACAN;CCND1;CHST11;PTPRZ1;MYC;PLXNA2;SLIT1;MBP;SLIT3;SOX9;SLIT2;NGFR;EGR1;SEMA6A;TGFB1;NOS2;BDNF;PRKCA;TACR1;FOS;MMP9;GFAP;RGMA;GRIN1;BCAN;VCAN;COL2A1;GDNF;COL4A1;PTPRA;CSPG4;LTB TGF Beta Signaling Pathway WP113 24/52 1.7505503684763404E-4 0.0012180912980647868 0 0 2.9065123738247225 25.142524102465934 ZFP423;JUN;SMAD4;TGFB1;SMAD3;FST;NOG;LEF1;SMAD9;FOS;INHBA;SMAD6;RUNX3;THBS1;LTBP1;RUNX2;NFKB1;TGFBR2;TGFBR3;SKI;ZEB2;ITGB6;WNT1;JAK1 Nuclear Receptors WP509 19/38 2.2596436804244653E-4 0.0015094419785235428 0 0 3.3891820580474934 28.45263493379802 THRB;VDR;NR1I2;ESRRB;NR2F1;RORA;NR2E1;NR2F2;ESR1;ESR2;NR2F6;NR5A1;NR4A2;RXRA;PPARG;PGR;ROR1;PPARA;RXRG Insulin Signaling WP65 56/159 2.525843850813371E-4 0.0016223689349455113 0 0 1.8476518026054973 15.305513642685492 SNAP25;IRS1;CBLC;PIK3CD;IRS3;PIK3C2A;PIK3CG;IGF1R;RPS6KA4;LIPE;GRB14;GYG;GRB10;FLOT1;AKT1;ENPP1;FLOT2;MAP3K8;MAP3K9;MAP3K6;MAP3K5;PRKCH;PRKCB;PRKCD;GAB1;PRKCA;FOS;TBC1D4;RHOJ;SGK1;SOS2;SHC2;SHC3;PRKAA2;RRAD;STXBP1;SRF;FOXO3;PRKCZ;SOCS1;MAPK7;EIF4E;SH2B2;MAPK4;MAP2K6;EGR1;JUN;INSR;MAPK12;MAPK13;ARHGAP33;EHD2;MAPK11;MYO1C;MAP3K10;MAP3K14 Regulation of Actin Cytoskeleton WP523 53/152 4.8006168400255495E-4 0.0029692704158676545 0 0 1.818589080884163 13.896922962436935 CHRM2;CHRM3;CHRM1;CHRM4;PIK3CD;PIK3C2A;FGF2;FGF3;PIK3CG;MYLK;PIK3C2B;FGF5;FGF8;FGF9;PIP5KL1;PIP4K2A;RAC3;GIT1;APC2;PDGFRA;ITGA1;F2;VAV1;MRAS;ARHGEF7;SOS2;DOCK1;PDGFB;PDGFA;EGFR;PIK3R5;FGF20;PAK7;PAK6;CD14;FGF23;MAPK4;FGF21;GSN;ARPC5;GNG12;BAIAP2;MOS;FGF15;FGF14;FGF18;FGFR4;FGFR3;FGF12;FGFR2;FGF11;FGFR1;FGF10 Gene regulatory network modelling somitogenesis WP2852 8/11 6.167863159372966E-4 0.0036786898129117338 0 0 9.025371060905169 66.70640849853362 LFNG;MESP2;HES7;RIPPLY2;NOTCH1;FGF8;WNT3A;DLL1 White fat cell differentiation WP2872 16/32 7.017329817908391E-4 0.004041014067554143 0 0 3.3876071193144366 24.600659245986794 CEBPA;STAT5B;TLE3;WNT10B;CEBPB;ZFP423;EGR2;CEBPD;EBF1;RORA;GATA3;NR2F2;GATA2;MECOM;IRF4;PPARG Focal Adhesion WP85 61/185 9.89269438863806E-4 0.005441247595623837 0 0 1.6713360680383145 11.563211837688275 FLT1;ITGB5;LAMC3;ITGB4;ITGB3;ITGA2B;TNC;PIK3CD;LAMC2;PIK3CG;MYLK;CCND2;CCND1;AKT1;RAC3;ITGB8;ITGB6;PDGFRA;ITGA4;ITGA2;PGF;VAV1;COL2A1;COL4A2;COL4A1;COL6A2;ITGA7;DOCK1;MET;SHC3;TNXB;LAMA4;LAMA3;COL11A2;PDGFB;PDGFA;THBS2;THBS1;EGFR;THBS4;PIK3R5;VTN;RELN;MAPK7;ERBB2;PAK7;PAK6;MAPK4;MAP2K6;JUN;SRMS;CAV1;LAMB1;MAPK12;VEGFA;COL1A1;COL1A2;COL5A1;ITGA11;BCL2;ZYX Id Signaling Pathway WP512 22/51 0.0010100519488882573 0.005441247595623837 0 0 2.5711315959182124 17.73503200303805 ACVRL1;TCF7L2;SMAD4;FLT1;SMAD3;IRS1;PAX5;NGF;PAX2;BMP6;NFKB1;IGF1R;VEGFA;BMP2;PAX8;MYOD1;ID1;KDR;ID4;ID3;MSC;ATF3 Splicing factor NOVA regulated synaptic proteins WP1983 19/42 0.0010984673880567463 0.005732626681421145 0 0 2.7990325417766053 19.072158087080886 NTNG1;GABBR2;KCNJ6;CADM3;CADM1;CLSTN1;GRIK2;ANK3;EFNA5;PRKCZ;GRIN2B;RAP1GAP;GRIN1;CDH2;CHL1;KCNQ2;KCNMA1;NCDN;MAPK4 Metapathway biotransformation WP1251 47/141 0.002772642279233103 0.014031250322179641 0 0 1.69679203539823 9.990634337764623 UGT1A10;HS3ST3A1;GAL3ST1;CYP46A1;HS6ST2;HS6ST3;NDST2;CYP27B1;CYP26B1;CHST11;CYP2R1;CYP4V3;UGT1A5;CYP1B1;CHST13;CHST14;UGT1A2;UGT1A9;GAL3ST3;SULT4A1;CHST8;HS3ST3B1;GSTK1;CHST7;GPX3;GSTO1;KCNAB1;HS3ST5;KCNAB2;HS3ST6;KCNAB3;UGT1A6A;HS3ST4;HS3ST1;HS3ST2;SULT2B1;CYP26A1;CYP26C1;CYP24A1;CYP2U1;CYP1A1;CHST1;NAT8L;CHST5;CHST2;GSTM5;CHST3 ErbB signaling pathway WP1261 19/46 0.00394803250913642 0.019391806736052418 0 0 2.383742141437832 13.19291128071362 CDKN1A;SHC2;JUN;CDKN1B;CAMK2A;GAB1;TGFA;CBLC;PRKCA;NRG2;AREG;EGFR;PIK3R5;EREG;ERBB3;NRG3;ERBB4;MYC;ERBB2 Ptf1a related regulatory pathway WP201 7/11 0.004396194412828938 0.020976127626926647 0 0 5.921217105263158 32.13454007916281 RBPJL;NOTCH1;PDX1;PROX1;NKX6-1;PTF1A;FGF10 MAPK signaling pathway WP493 51/159 0.004598113942464549 0.021330139677543884 0 0 1.6024813010530459 8.624729148224791 PTPRR;ARRB1;CASP7;PPP3CC;MYC;AKT1;MAP3K8;MAP3K6;MAP3K5;DUSP4;DUSP5;MEF2C;PRKCH;PRKCB;PRKCD;FOS;NGF;TGFBR2;DUSP7;TMEM37;MRAS;MAPKAPK2;RASA2;MAPT;SOS2;SRF;PDGFB;PLA2G5;PRKCZ;RASGRP1;EGFR;NTF5;ACVR1C;MAPK7;CD14;MAPK4;MAP2K6;NTRK1;TGFB2;JUN;TGFB1;TGFB3;BDNF;NFKB1;GCK;MAPK12;MAPK13;MOS;MAP3K14;PTPN5;HSPA1A GPCRs, Class B Secretin-like WP456 11/22 0.004808261029646038 0.02170215113380779 0 0 3.3849868305531166 18.067095706851475 GLP1R;VIPR1;ADCYAP1R1;VIPR2;CALCR;GCGR;SCTR;PTH2R;PTH1R;CRHR1;CRHR2 Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling WP3675 14/31 0.004943335707644088 0.021724659557277967 0 0 2.7883877469283345 14.805544053826303 SMAD3;IGFBP5;IRS1;IGFBP4;IGFBP3;PLD1;PRKAB1;NFKB1;IGF1R;TNFRSF1A;AKT1;TNFSF9;IGFBP7;IGFBP6 Delta-Notch Signaling Pathway WP265 29/83 0.008099093137229816 0.03468073215172767 0 0 1.8199851460098264 8.765054254263655 APP;NOTCH3;HDAC2;NOTCH1;LEF1;DTX1;FURIN;ASCL1;DLL1;EGFR;LFNG;DLL4;HEY1;HEY2;AKT1;HIVEP3;JAK2;HES5;JAG2;HES6;MEF2C;JUN;SMAD4;SMAD3;JAG1;RING1;CNTN1;MAML3;ZFPM1 Leptin Insulin Overlap WP578 9/18 0.010596886111628121 0.04316292635711942 0 0 3.3839403247038176 15.387436809295966 SOCS1;IRS1;INSR;LEP;LEPR;AKT1;IRS3;JAK2;PIK3CG Small Ligand GPCRs WP353 9/18 0.010596886111628121 0.04316292635711942 0 0 3.3839403247038176 15.387436809295966 PTGER4;PTGFR;PTGER1;TBXA2R;CNR1;PTGER2;PTGER3;S1PR1;S1PR3 Peptide GPCRs WP234 25/71 0.011989114652311466 0.04763456064990739 0 0 1.8411492734478203 8.1447954273319 OPRD1;OXTR;NPY2R;CXCR4;MC4R;GALR3;GALR2;GALR1;NTSR1;CCR10;NTSR2;GHSR;LHCGR;NPY5R;TACR3;TACR1;SSTR1;AVPR1A;NMBR;AGTR1A;SSTR4;GCAT;TSHR;SSTR5;CCKBR Mecp2 and Associated Rett Syndrome WP2910 18/47 0.012265186275125855 0.04763456064990739 0 0 2.101803352006125 9.25001640397943 GAMT;RBFOX1;MEF2C;CEBPD;ARHGEF26;DLX5;BDNF;GAD1;TAP1;FGF2;POU3F2;POU4F1;FGF3;GRIN1;REST;BCL6;GPRIN1;MBP Serotonin and anxiety-related events WP2140 7/13 0.01478513733172116 0.056116316690850765 0 0 3.9469663742690058 16.63304060488014 NLGN1;PRKCB;HTR1A;CRH;FOS;CRHR1;GRIN2D Matrix Metalloproteinases WP441 12/29 0.019886020575111314 0.07379923191207977 0 0 2.3889972234777557 9.35946586790912 MMP23;MMP25;MMP24;MMP16;MMP15;MMP2;MMP28;MMP17;TIMP2;TIMP3;TCF20;MMP9 Retinol metabolism WP1259 15/39 0.020398684225212124 0.07405609273066141 0 0 2.115690905096661 8.234871718495231 CRABP2;CRABP1;LPL;DHRS3;SULT2B1;CYP26A1;ALDH1A3;CYP26B1;RBP4;RXRA;RDH10;ALDH1A2;RBP1;LRAT;RXRG Alpha6-Beta4 Integrin Signaling Pathway WP488 23/67 0.021250654527367442 0.07550764481000773 0 0 1.7703014964788732 6.818081795317841 DSP;CDKN1A;RTKN;CD151;SMAD3;IRS1;ITGB4;PRKCD;LAMA3;TRP73;PIK3CD;LAMC2;PRKCA;LAMB1;MST1R;NTN1;PIK3CG;EGFR;ERBB2;AKT1;MET;EIF4E;PLEC GPCRs, Class A Rhodopsin-like WP189 65/228 0.026338180945433633 0.09163492120598785 0 0 1.3525685925546382 4.918934413648433 GPR27;CHRM2;CHRM3;OXTR;CHRM1;CHRM4;NPY2R;OXT;ADRA1D;HTR4;ADRA1B;ADRA1A;MC4R;HTR6;HTR7;LHCGR;GPR37;NPY5R;AVPR1A;SSTR1;ADRA2C;ADRA2B;GCAT;AGTR1A;ADRA2A;SSTR4;SSTR5;CCKBR;ADORA2A;ADORA2B;AVP;OPRD1;PTGER4;PTGFR;GPR45;PTGER1;PTGER2;PTGER3;CXCR4;ADRB1;GPR83;HRH1;P2RY6;GALR3;GALR2;HRH2;TBXA2R;CNR1;GALR1;P2RY2;P2RY1;NTSR1;DRD4;NTSR2;GPR12;HTR1F;HTR1D;HTR1A;HTR1B;GPR50;NMBR;GPR3;HTR5A;HTR5B;TSHR Type II interferon signaling (IFNG) WP1253 13/34 0.031317062139957 0.10673366076271058 0 0 2.095028964594182 7.256326009171868 CIITA;NOS2;IFNGR2;PRKCD;TAP1;ISG15;PSMB9;SOCS1;IRF4;IRF2;IRF8;JAK2;JAK1 EDA Signalling in Hair Follicle Development WP3652 8/18 0.034777034917094864 0.11387774178734984 0 0 2.706382978723404 9.090193807125257 EDARADD;SHH;BMP1;LTB;DKK1;NFKB1;WNT3;NFKB2 Serotonin and anxiety WP2141 8/18 0.034777034917094864 0.11387774178734984 0 0 2.706382978723404 9.090193807125257 CAMK2B;GABRA1;PRKCB;HTR1A;CRH;FOS;ADRA1A;GRM1 Nucleotide GPCRs WP207 6/12 0.03611039509127999 0.11596992269699535 0 0 3.382372286779215 11.233448596565747 P2RY6;ADORA2A;ADORA2B;P2RY2;P2RY1;ADORA1 Hedgehog Signaling Pathway WP116 9/22 0.04472940324681293 0.14093981777769357 0 0 2.3421203631822323 7.2772588664446625 SKI;SHH;SMO;DHH;HHIP;IHH;IGF2;GAS1;GLI3 Dysregulated miRNA Targeting in Insulin/PI3K-AKT Signaling WP3855 10/26 0.05354590643635337 0.16559567360872246 0 0 2.114466754443713 6.189500764474778 COL1A1;CDKN1B;BCL2L11;SOCS1;CCND2;COL1A2;COL4A2;PRKAR2A;BCL2;FLOT2 Osteoblast WP238 5/10 0.05531307434051133 0.1679506075430071 0 0 3.381850065760631 9.789596858171768 COL1A1;PDGFRA;TNFSF11;PTH1R;FGF23 MicroRNAs in Cardiomyocyte Hypertrophy WP1560 25/82 0.0672520129998359 0.2005551101959392 0 0 1.484777553747866 4.007872415858805 CAMK2D;LRP5;PIK3CD;GATA4;FGF2;PIK3CG;IGF1R;MYLK;HDAC7;MAPK7;AKT1;PRKG1;MAPK4;MAP2K6;FZD1;EDN1;TGFB1;FZD2;PRKCB;WNT3A;WNT5A;NFKB1;PLCB2;MAP3K14;FGFR2 Osteoclast WP454 6/14 0.07731410453734673 0.2265167624164369 0 0 2.5364503398377547 6.493005642756823 GPR68;ITGB3;PDGFB;ACP5;TNFSF11;TNFRSF11A IL-6 signaling Pathway WP387 29/99 0.0813004757246679 0.22947978144555717 0 0 1.402527859976075 3.5197887013814086 CEBPB;IL6RA;FOXO3;ERBB3;ERBB2;AKT1;JAK2;EIF4E;MAP2K6;JAK1;LYN;NCOA1;STAT5B;JUN;PRKCD;GAB1;GAB2;FOS;NFKB1;VAV1;TEC;CDK5;PPP2R2C;FES;PPP2R2B;MAPKAPK2;MAPT;SGK1;CDK5R1 EGFR1 Signaling Pathway WP572 49/178 0.08153509274097466 0.22947978144555717 0 0 1.286663852771515 3.2253082847942123 PTPRR;HIP1;CBLC;PIK3CD;PIK3CG;PIK3C2B;GRB14;MYC;GRB10;AKT1;JAK2;GIT1;JAK1;VAV3;PRKCB;SH2D3C;KRT8;GAB1;KRT7;PRKCA;GAB2;FOS;DNM1;VAV1;VAV2;DOK2;PRKD1;SOS2;PLEC;CEBPA;CEBPB;STXBP1;RGS16;CAMK2A;PLD1;PRKCZ;EGFR;SOCS1;MAPK7;PLCG2;EPS15;SNCA;STAT5B;JUN;SMAD3;CAV1;KRT18;MAP3K14;PTPN5 IL-2 Signaling Pathway WP450 23/76 0.08244782566906246 0.22947978144555717 0 0 1.4688247408982196 3.6655837503013995 LYN;STAT5B;IRS1;PIK3CD;GAB2;NMI;SHB;FOXO3;ETS1;PRKCZ;PIK3CG;VAV1;NFKB1;SOCS1;MKNK1;MAPKAPK2;BCL2;AKT1;JAK2;PLCB1;JAK3;EIF4E;JAK1 Eicosanoid Synthesis WP318 7/18 0.09425574026431903 0.2580444036744472 0 0 2.1521929824561403 5.082927894342673 PTGIS;ALOX5;ALOX15;ALOX5AP;ALOX12;LTC4S;PTGS1 Signal Transduction of S1P Receptor WP57 8/22 0.10743720350461294 0.2893873062140381 0 0 1.9326293360072697 4.311403749159602 MAPK7;SPHK1;S1PR1;AKT1;S1PR3;S1PR5;GNAI1;MAPK12 Kit Receptor Signaling Pathway WP407 20/67 0.11232676607166146 0.29775507831694387 0 0 1.4399019227079815 3.148119635228006 LYN;PTPRU;STAT5B;PRKCB;MATK;PRKCA;PIK3CG;VAV1;EPOR;VAV2;DOK1;SOCS1;TEC;FES;KITL;GRB10;AKT1;JAK2;MPDZ;SH2B2 Inflammatory Response Pathway WP458 10/30 0.1261435467714192 0.3240918817050309 0 0 1.6911345183234585 3.5012145778047086 COL1A1;VTN;COL1A2;CD80;IL4RA;LAMC2;LAMB1;TNFRSF1B;THBS1;TNFRSF1A Nuclear receptors in lipid metabolism and toxicity WP431 10/30 0.1261435467714192 0.3240918817050309 0 0 1.6911345183234585 3.5012145778047086 ABCC3;CYP27B1;CYP26A1;CYP24A1;VDR;ABCB4;NR1I2;PPARG;ABCB1A;PPARA IL-3 Signaling Pathway WP373 28/100 0.13346029320043076 0.33506482176865776 0 0 1.3160877334704169 2.6505365682988655 PIK3CD;GATA2;BCL2L11;RXRA;MAPK7;AKT1;JAK2;JAK1;LYN;STAT5B;PRKCB;MMP2;KCNIP3;MATK;GAB1;PRKCA;GAB2;TNFRSF1B;MMP9;NFKB1;DNM1;VAV1;MRAS;TEC;FES;MAPKAPK2;ID1;BCL2 Robo4 and VEGF Signaling Pathways Crosstalk WP3864 3/6 0.13668928749731815 0.33506482176865776 0 0 3.380806310254163 6.727956367020931 KDR;SLIT2;VEGFA mir-193a and MVP in colon cancer metastasis WP3979 3/6 0.13668928749731815 0.33506482176865776 0 0 3.380806310254163 6.727956367020931 CCND2;CCND1;MYC Lung fibrosis WP3632 18/61 0.13843995629962505 0.33506482176865776 0 0 1.41620698645754 2.800292381610648 DSP;EDN1;CEBPB;TGFB1;ELN;SFTPC;MMP2;IL13;PDGFB;TGFA;PDGFA;ATP11A;FGF2;MMP9;BMP7;GREM1;PLAU;PTX3 IL-5 Signaling Pathway WP151 20/69 0.14163642039771987 0.33790403152027454 0 0 1.3809508848624121 2.6990573527269737 LYN;STAT5B;SHC2;JUN;CDKN1B;PRKCB;PRKCD;FOXO3;PIK3CG;VAV1;RAP1GAP;NFKB1;SOCS1;ALOX5;ALOX5AP;AKT1;JAK2;SOX4;SH2B2;JAK1 Apoptosis WP1254 23/81 0.14455961156490116 0.3395605081037874 0 0 1.3417655718795531 2.5950595762329978 HRK;JUN;TRADD;TRP73;IGF2;TNFRSF1B;NFKB1;IGF1R;TNFRSF1A;CASP7;BCL2L11;IRF4;MYC;IRF2;LTA;BCL2;AKT1;PMAIP1;IRF5;TNFRSF25;IRF6;NFKBIE;TNFRSF21 Notch Signaling Pathway WP29 14/46 0.14639734481121372 0.3395605081037874 0 0 1.4798896332088733 2.843505542795804 RBPJL;JAG2;NOTCH3;HDAC2;NOTCH1;JAG1;DTX1;DTX4;DLL1;DLL3;DLL4;LFNG;MAML3;HES5 Prostaglandin Synthesis and Regulation WP374 10/31 0.14998307471142963 0.34311196543573624 0 0 1.6104998066815053 3.055493100323184 PTGER4;PTGFR;HSD11B2;EDN1;PTGIS;HPGD;PTGER1;PTGER2;PTGER3;PTGS1 TYROBP Causal Network WP3625 17/58 0.15384324968255272 0.3471867932025176 0 0 1.4026480836236934 2.625506214480403 RBM47;KCNE3;IL10RA;LOXL3;LHFPL2;TNFRSF1B;RUNX3;ZFP36L2;CXCL16;APBB1IP;LYL1;MAF;ADAP2;ELF4;HLX;DPYD;SH2B3 Parkinsons Disease Pathway WP3638 12/39 0.16036877842241537 0.35708781328724487 0 0 1.5032077082571045 2.7512898779685746 MAPK11;CASP7;GPR37;LRRK2;UBE2L6;SNCAIP;SEPT5;SLC6A3;MAPK12;UBE2J1;SNCA;MAPK13 Alzheimers Disease WP2075 21/75 0.1752196863498226 0.385022205531847 0 0 1.3156010167668768 2.2914016852061496 APP;ITPR2;LPL;CACNA1D;CACNA1C;GRIN2C;GRIN2B;TNFRSF1A;GRIN2D;GRIN1;CASP7;GRIN2A;PPP3CC;CDK5;CAPN2;MAPT;CACNA1S;PLCB1;PLCB2;SNCA;CDK5R1 Integrin-mediated Cell Adhesion WP6 27/100 0.18927752514243643 0.40766177078153276 0 0 1.2513427071389778 2.0829111834613223 SHC3;ITGB5;ITGB4;ITGB3;ITGA2B;MAPK7;CAPN2;AKT1;RAC3;ITGB8;PAK6;ITGB6;MAPK4;TNS1;MAP2K6;VAV3;ITGA4;CAV1;ITGA2;ITGA1;MAPK12;VAV2;ITGA11;ZYX;ITGA7;ARHGEF7;DOCK1 One carbon metabolism and related pathways WP1770 15/52 0.19040489892790152 0.40766177078153276 0 0 1.3711822543105496 2.274246215259915 DMGDH;GPX3;SHMT2;BHMT2;GAD1;DNMT3A;GAD2;PLD1;SOD3;DNM1;GNMT;CBS;ETNK2;CHDH;CDO1 Estrogen metabolism WP1264 5/14 0.19789082114926207 0.41753034846541565 0 0 1.878318476301817 3.0429507050372187 CYP1A1;CYP1B1;UGT1A2;UGT1A9;UGT1A6A Hfe effect on hepcidin production WP3673 3/7 0.20001453818702547 0.41753034846541565 0 0 2.535440403155127 4.08044961271947 ID1;HFE2;BMP6 EPO Receptor Signaling WP1249 8/26 0.2265341493711215 0.46705188820959614 0 0 1.5027662011649727 2.2313967836476523 PTPRU;STAT5B;SOCS1;IRS1;AKT1;JAK2;PIK3CG;EPOR Chemokine signaling pathway WP2292 48/190 0.23520162733098154 0.4790081922472429 0 0 1.1437903811450245 1.6554217088871899 SHC4;SHC2;SHC3;NCF1;PIK3CD;ADCY3;CXCR4;ARRB1;ADCY2;ADCY1;FOXO3;ADCY8;CXCL14;PRKCZ;ADCY7;CX3CL1;CXCL5;PIK3CG;ADCY6;GNAI1;CXCL16;PIK3R5;ADCY5;PREX1;GNG4;GNG7;AKT1;GNG8;JAK2;JAK3;CCR10;LYN;VAV3;STAT5B;PRKCB;PRKCD;GNG12;NFKB1;VAV1;VAV2;TIAM2;TIAM1;ADCY9;CXCL12;ELMO1;PLCB1;SOS2;PLCB2 Biogenic Amine Synthesis WP522 5/15 0.2444177858036679 0.49178036420738 0 0 1.6903770276194652 2.3815321001520933 PNMT;ACHE;GAD1;CHAT;GAD2 Glucuronidation WP1241 5/16 0.29338079007583096 0.5757873283272714 0 0 1.5366067514248136 1.8843161028691087 UGT1A10;UGP2;UGT1A5;PGM5;UGT1A2 Oxidation by Cytochrome P450 WP1274 11/40 0.29476944021044105 0.5757873283272714 0 0 1.2824619297024007 1.5666064863850575 CYP27B1;CYP26A1;CYP26B1;CYP24A1;CYP26C1;CYP2U1;CYP2R1;CYP4V3;CYP1A1;CYP1B1;CYP46A1 p38 MAPK Signaling Pathway WP350 10/36 0.2965132349469781 0.5757873283272714 0 0 1.3003663003663004 1.580807749525036 TGFB2;TRADD;MKNK1;MYC;RASGRF1;MAPKAPK2;MAP3K9;MEF2D;MAP3K5;MAP2K6 Striated Muscle Contraction WP216 12/45 0.32248879332861113 0.6188228200380267 0 0 1.2294182217343579 1.3913164872063433 TMOD1;MYL4;ACTA1;MYBPC2;DES;JSRP1;MYH3;TPM2;TNNC2;TPM1;MYL9;TTN Microglia Pathogen Phagocytosis Pathway WP3626 11/41 0.32608627642722365 0.6188228200380267 0 0 1.2396327187591454 1.3891240955644348 LYN;VAV3;NCF1;ARPC1B;PLCG2;PIK3CD;RAC3;PIK3C2A;PIK3CG;VAV1;VAV2 miR-127 in mesendoderm differentiation WP3991 3/9 0.33882913695576666 0.6357805154113824 0 0 1.6900744960560912 1.8290988739084624 SMAD4;T;FOXA2 Purine metabolism WP2185 41/171 0.38946742145651236 0.7184098338897252 0 0 1.0663567762330466 1.0055478441217045 GUCY2E;GDA;PDE1B;NPR1;NPR2;PDE3B;GMPR;ADCY3;AK4;ADCY2;AK5;ADCY1;ADCY8;NT5C2;ADCY7;AK8;ADCY6;PAPSS2;ADCY5;NT5E;PDE11A;ENPP1;PDE4A;NUDT16;PDE8B;PDE8A;POLR2L;ENTPD2;ENTPD3;POLR3GL;PDE4D;PDE2A;PDE4C;AMPD3;ADCY9;PDE10A;IMPDH1;NT5C1A;PDE3A;ADSSL1;PDE5A PluriNetWork WP1763 69/292 0.3946096074480725 0.7184098338897252 0 0 1.046294616241997 0.9729057733159392 CDKN1A;PTPRS;IRS1;PIK3CD;CABIN1;FGF5;SHH;CCND1;ZIC2;SALL3;DPYSL2;MYC;DNMT3B;AKT1;JAK1;NCOA1;KDM6B;FOXD3;MEF2C;TLE2;IGFBP3;WNT5A;DNMT3A;GAB1;FOS;DKK1;SMO;MYOD1;HAND2;SGK1;CD44;RTN4R;HDAC2;NOTCH1;SATB1;NPR1;SATB2;TCF7;LEF1;GATA6;LRP5;TWIST1;NKD1;ACVR1C;T;GBX2;MEF2D;FZD1;TFAP2A;TFAP2C;SMAD4;TGFB1;SMAD3;CDX2;CDKN2A;WNT3A;INSR;ESRRB;NR2F1;INHBB;NR2F2;SMARCA2;NFKB1;NR2F6;DAZL;OCLN;REST;ID1;FGFR1 Keap1-Nrf2 WP1245 4/14 0.4016796664181787 0.7184098338897252 0 0 1.3520052596975674 1.2331644810130222 CEBPB;MAF;PRKCA;EPHB2 Irinotecan Pathway WP475 3/10 0.40867625281152037 0.7184098338897252 0 0 1.448541379742081 1.2962011716675836 UGT1A10;UGT1A9;UGT1A6A Leptin and adiponectin WP683 3/10 0.40867625281152037 0.7184098338897252 0 0 1.448541379742081 1.2962011716675836 LEP;LEPR;PRKAB1 Macrophage markers WP2271 3/10 0.40867625281152037 0.7184098338897252 0 0 1.448541379742081 1.2962011716675836 CD83;CD14;F3 Regulation of Cardiac Hypertrophy by miR-208 WP1526 2/6 0.41404440412392474 0.7202647446739107 0 0 1.689923329682366 1.490144065713751 GATA4;HOPX Triacylglyceride Synthesis WP386 6/23 0.4333233344591174 0.746030895408996 0 0 1.1929272476366122 0.9976105801599247 LIPE;DGAT2;MOGAT1;GPD1;LPL;AGPAT3 Hypertrophy Model WP202 5/20 0.4943555117662671 0.8424221476017 0 0 1.1265526815724098 0.793656771054952 NR4A3;EIF4E;ATF3;DUSP14;VEGFA Acetylcholine Synthesis WP175 2/7 0.4996563047775644 0.8428545747257904 0 0 1.3518510405257393 0.9379613062906348 ACHE;CHAT Novel Jun-Dmp1 Pathway WP3654 6/26 0.5642535583959147 0.936254942195753 0 0 1.0137908353431264 0.5801433838830388 JUN;CCND1;CDKN2A;MYC;FOS;ETS1 Apoptosis Modulation by HSP70 WP166 4/17 0.5664168674630768 0.936254942195753 0 0 1.0398017498609216 0.5910492648706145 CASP7;NFKB1;TNFRSF1A;HSPA1A Exercise-induced Circadian Regulation WP544 11/49 0.5811303613778638 0.936254942195753 0 0 0.9781491151055867 0.530919946067438 PER2;CLDN5;CEBPB;UGP2;STBD1;UCP3;CRY2;CRY1;GFRA1;TUBB4A;ARNTL p53 signaling WP2902 15/67 0.5822167320924158 0.936254942195753 0 0 0.9746983574422063 0.527226533710836 STEAP3;CDKN1A;CD82;GADD45B;CDKN2A;IGFBP3;TRP73;THBS1;BBC3;GADD45G;CCND2;CCND1;ZMAT3;PMAIP1;RPRM Glutathione and one carbon metabolism WP730 7/31 0.5830569699901695 0.936254942195753 0 0 0.9855902777777777 0.5316967604217051 SHMT2;CBS;GPX3;CHDH;DNMT3A;DNMT3B;OPLAH Cytokines and Inflammatory Response WP222 6/27 0.6046007035344245 0.9616030237166561 0 0 0.965452438375043 0.48580314796980134 IL11;TGFB1;CSF1;IL7;IL13;PDGFA MAPK Cascade WP251 6/28 0.6428100444241308 0.9792770653576263 0 0 0.9215084411313309 0.407220126872286 JUN;RASA3;MBP;MAPK12;SIPA1;MAP2K6 Oxidative Stress WP412 6/28 0.6428100444241308 0.9792770653576263 0 0 0.9215084411313309 0.407220126872286 NFIX;GPX3;CYP1A1;FOS;SOD3;NFKB1 ACE Inhibitor Pathway WP396 2/9 0.6447030687653144 0.9792770653576263 0 0 0.9654827100610233 0.42381352978111064 ACE;AGTR1A Eicosanoid Lipid Synthesis Map WP4335 2/9 0.6447030687653144 0.9792770653576263 0 0 0.9654827100610233 0.42381352978111064 ALOX5;PLA2G5 Oxidative Damage WP1496 9/42 0.6450327975409514 0.9792770653576263 0 0 0.9214567792891619 0.40401651628551777 CDKN1C;CDKN1A;CDKN1B;BCL2;MAP3K9;TNFRSF1B;NFKBIE;NFKB1;MAPK13 IL-9 Signaling Pathway WP10 5/24 0.6699527864342544 0.9999964152577399 0 0 0.889152956921018 0.35614847156631624 STAT5B;IRS1;AKT1;JAK3;JAK1 Alanine and aspartate metabolism WP240 3/15 0.7004095688078675 0.9999964152577399 0 0 0.8447085889570553 0.3007922955864046 GAD1;GAD2;ABAT Iron Homeostasis WP1596 3/15 0.7004095688078675 0.9999964152577399 0 0 0.8447085889570553 0.3007922955864046 TFR2;IL6RA;HFE2 IL-7 Signaling Pathway WP297 9/44 0.7027992402030521 0.9999964152577399 0 0 0.8686892747445621 0.3063728114486148 LYN;STAT5B;BCL2L11;CCND2;IRS1;AKT1;FOXO3;JAK3;JAK1 Ethanol metabolism resulting in production of ROS by CYP2E1 WP4265 2/10 0.7037097101418812 0.9999964152577399 0 0 0.8447426067907996 0.29683355670822054 PRKCD;MAFK Histone modifications WP300 1/5 0.7264487399620718 0.9999964152577399 0 0 0.8447766097240473 0.2699799230959754 HDAC2 Synthesis and Degradation of Ketone Bodies WP543 1/5 0.7264487399620718 0.9999964152577399 0 0 0.8447766097240473 0.2699799230959754 ACAT1 Eicosanoid metabolism via Cyclo Oxygenases (COX) WP4347 6/31 0.7431553157235926 0.9999964152577399 0 0 0.810769568077176 0.2406771225863418 PTGFR;PTGIS;HPGD;TBXA2R;PLA2G5;PTGS1 GPCRs, Other WP41 32/155 0.7704533291218726 0.9999964152577399 0 0 0.8782997642545334 0.2290396734496607 VIPR1;GPR88;GPR83;ADRB1;GPR84;CELSR1;CELSR2;CELSR3;GRM1;MC4R;PROKR1;CALCR;CNR1;ADORA1;S1PR1;DRD2;S1PR5;CCR10;DRD5;FZD1;GHSR;CASR;FZD2;IRX6;HTR1D;FZD9;HTR1A;TACR3;PTH2R;SSTR5;GPR162;SMO Eicosanoid metabolism via Lipo Oxygenases (LOX) WP4348 6/32 0.7716624942208238 0.9999964152577399 0 0 0.7795355269593375 0.2020618512656535 HPGD;ALOX5;ALOX15;ALOX12;LTC4S;PPARA EBV LMP1 signaling WP1243 4/22 0.7744620683579545 0.9999964152577399 0 0 0.7507244259381012 0.19187510054156115 TRADD;MAP3K14;NFKB1;NFKB2 Non-homologous end joining WP1242 1/6 0.7889295102173339 0.9999964152577399 0 0 0.6757774857643452 0.1602121793885818 RAD50 Folic Acid Network WP1273 4/23 0.8048724361051891 0.9999964152577399 0 0 0.7111664763486626 0.15437395854179783 PTGIS;GPX3;CBS;ALOX5 Signaling of Hepatocyte Growth Factor Receptor WP193 6/34 0.821437379163068 0.9999964152577399 0 0 0.7237604535346258 0.14236337132799035 JUN;ITGA1;GAB1;FOS;MET;DOCK1 Fatty Acid Omega Oxidation WP33 1/7 0.837141614725479 0.9999964152577399 0 0 0.5631114031245438 0.10009982590120893 CYP1A1 G1 to S cell cycle control WP413 11/61 0.853535095347485 0.9999964152577399 0 0 0.7428138718173837 0.11763840650690491 CDKN1C;CCNA1;CDKN1A;CDKN2B;CDKN1B;CCND2;CDKN2C;CCND1;CDKN2A;MYC;E2F6 Blood Clotting Cascade WP460 3/20 0.8681396030187101 0.9999964152577399 0 0 0.5960715574573388 0.08428615401360404 PLAU;F12;F2 ApoE and miR-146 in inflammation and atherosclerosis WP3592 1/8 0.8743430172081503 0.9999964152577399 0 0 0.48263562981039987 0.06480952480982737 NFKB2 IL-1 Signaling Pathway WP37 6/37 0.8794791110835618 0.9999964152577399 0 0 0.6535918127745047 0.08393783312049707 AKT1;SIRPA;IRAK3;PRKCZ;MAP3K14;NFKB1 Toll Like Receptor signaling WP88 5/33 0.9014877888031693 0.9999964152577399 0 0 0.603001503100144 0.06253655134100825 MAL;IRAK3;NFKB1;MAP2K6;NFKB2 Methylation WP1247 1/9 0.9030479169810327 0.9999964152577399 0 0 0.42227879982479194 0.04306384959837894 PNMT NLR Proteins WP1256 1/9 0.9030479169810327 0.9999964152577399 0 0 0.42227879982479194 0.04306384959837894 EPHB2 Fatty Acid Beta Oxidation WP1269 5/34 0.9152895427926364 0.9999964152577399 0 0 0.5821705543545632 0.05153072389628794 LIPE;ACSS2;ACSL6;LPL;ACAT1 Selenium Micronutrient Network WP1272 3/23 0.9229831928659067 0.9999964152577399 0 0 0.5065622261174408 0.040598051661603816 PTGIS;GPX3;ALOX5 Fatty acid oxidation WP2318 1/10 0.9251965151448867 0.9999964152577399 0 0 0.3753345987248747 0.029181932965495837 SLC25A29 SREBF and miR33 in cholesterol and lipid homeostasis WP2084 1/11 0.9422860375381411 0.9999964152577399 0 0 0.33777923784494085 0.02007976012597688 PPARA Orphan GPCRs WP1398 2/19 0.9519868175197056 0.9999964152577399 0 0 0.3972939887893821 0.019548489748906946 GPR155;WLS Glutathione metabolism WP164 2/20 0.9613031134034853 0.9999964152577399 0 0 0.37519776073992944 0.014807369167296545 GPX3;OPLAH G13 Signaling Pathway WP298 5/39 0.9616887702469539 0.9999964152577399 0 0 0.49639605951981847 0.019391416368617333 RTKN;ARHGDIG;PIK3CD;PIP4K2A;RHPN2 Homologous recombination WP1258 1/13 0.9656455247281351 0.9999964152577399 0 0 0.28144619652504016 0.009838926655990444 RAD50 Glycogen Metabolism WP317 4/34 0.9680945915317158 0.9999964152577399 0 0 0.45008400905836804 0.01459418911371204 UGP2;GYG;PPP2R2C;PPP2R2B Glucocorticoid & Mineralcorticoid Metabolism WP495 1/14 0.9734950176516975 0.9999964152577399 0 0 0.2597796421712322 0.006978349382902753 HSD11B2 Kennedy pathway WP1771 1/14 0.9734950176516975 0.9999964152577399 0 0 0.2597796421712322 0.006978349382902753 ETNK2 Steroid Biosynthesis WP55 1/14 0.9734950176516975 0.9999964152577399 0 0 0.2597796421712322 0.006978349382902753 HSD17B1 Fatty Acid Biosynthesis WP336 2/22 0.9749982323393807 0.9999964152577399 0 0 0.3376341730558598 0.008548769288693497 ACSS2;ACSL6 One Carbon Metabolism WP435 3/29 0.9755411221454331 0.9999964152577399 0 0 0.3895115620575743 0.009645461126119205 SHMT2;DNMT3A;DNMT3B Estrogen signaling WP1244 11/77 0.9779083708311694 0.9999964152577399 0 0 0.5621524729294703 0.012558094814662028 SHC2;HDAC2;JUN;CCND1;BCL2;GNAS;AKT1;FOS;ESR1;NFKB1;HDAC7 Cholesterol Biosynthesis WP103 1/15 0.9795511999157348 0.9999964152577399 0 0 0.2412083098679682 0.004983549769874339 SQLE Cholesterol metabolism (includes both Bloch and Kandutsch-Russell pathways) WP4346 6/49 0.9801693078248306 0.9999964152577399 0 0 0.4708269810272125 0.009430645198002291 MYLIP;CH25H;SQLE;ELOVL4;ELOVL3;CYP46A1 Eicosanoid metabolism via Cytochrome P450 Mono-Oxygenases (CYP) pathway WP4349 1/16 0.9842237030133387 0.9999964152577399 0 0 0.22511315520513944 0.00357976454578581 PPARA Glycolysis and Gluconeogenesis WP157 6/51 0.9857386112348703 0.9999964152577399 0 0 0.44984287071548634 0.006461569847084442 HK3;PGK1;SLC2A5;ENO2;FBP1;GCK Mitochondrial Gene Expression WP1263 1/19 0.9927554555537489 0.9999964152577399 0 0 0.1875577943252056 0.0013637165157653198 CAMK4 Nucleotide Metabolism WP87 1/19 0.9927554555537489 0.9999964152577399 0 0 0.1875577943252056 0.0013637165157653198 IMPDH1 Statin Pathway WP1 1/19 0.9927554555537489 0.9999964152577399 0 0 0.1875577943252056 0.0013637165157653198 LPL Selenium metabolism/Selenoproteins WP108 5/50 0.9944087164064511 0.9999964152577399 0 0 0.3747868868430026 0.002101420079276999 JUN;GPX3;DIO3;FOS;NFKB1 PPAR signaling pathway WP2316 10/81 0.9944328254667316 0.9999964152577399 0 0 0.47479964271033265 0.002650677737357231 RXRA;FABP5;ACSL6;UCP1;LPL;PPARG;PLIN1;PPARA;APOA5;RXRG Tryptophan metabolism WP79 4/44 0.9951335257282413 0.9999964152577399 0 0 0.3373438527284681 0.0016456827722348816 ALDH1A2;CYP1A1;CYP1B1;ACAT1 Translation Factors WP307 4/50 0.9985289886534753 0.9999964152577399 0 0 0.29322813938198555 4.3165948604751727E-4 EEF1D;EEF1A2;EIF4E;EIF4G3 Proteasome Degradation WP519 4/52 0.9990210286139842 0.9999964152577399 0 0 0.28097377456351813 2.7520001397781583E-4 UBE2D1;PSMB8;H2-Q10;PSMB9 Complement and Coagulation Cascades WP449 5/62 0.9994348216737938 0.9999964152577399 0 0 0.2956536452925387 1.6714426999301605E-4 THBD;PLAU;F12;F2;F3 Odorant GPCRs WP1397 25/189 0.9997047547764787 0.9999964152577399 0 0 0.5124595912405623 1.513235864439107E-4 GPR27;GPR25;GPR26;GPR88;GPR85;GPR83;GPR84;GPR176;GPR153;GPR150;GPR139;GPR156;GPR155;GPR158;WLS;GPR135;GPR157;GPR37;GPR12;GPR3;GPR162;GPR149;GPR101;LGR6;LGR5 TNF-alpha NF-kB Signaling Pathway WP246 24/187 0.9998174562932234 0.9999964152577399 0 0 0.49490283035047516 9.034964377676563E-5 HDAC2;PEG3;CAV1;TRADD;USP2;GAB1;TNFAIP3;TNFRSF11A;MCC;TNFRSF1B;PRKCZ;NFKB1;NFKB2;TNFRSF1A;DAP;CASP7;TNIP2;KCNQ1;TIFA;AKT1;TNFRSF8;MAP3K8;NFKBIE;MAP3K14 Amino Acid metabolism WP662 7/95 0.9999814756303186 0.9999964152577399 0 0 0.2676809210526316 4.958666266466296E-6 PNMT;MPST;ARG2;PPM1L;CBS;P4HA2;ACSS1 mRNA processing WP310 48/457 0.9999935770845019 0.9999964152577399 0 0 0.3901765487853242 2.5060790503748308E-6 SF3B2;RBM47;ANKRD33B;EIF4E3;DDX4;RNPEPL1;DDX25;ABCB4;CELF2;CELF4;CELF5;MSI1;CELF6;ADARB2;TMEM163;ELAVL2;RPL7;ELAVL3;BOLL;ATXN1;ZFP385A;ZMAT4;RNPEP;SPOP;ADAD1;PAPOLB;EIF4E;SRSF12;RBM11;MRPS28;RBM38;LINGO1;RBFOX1;CIZ1;SYNJ2;BICC1;TTC39A;ENOX1;DAZL;CPEB1;RALYL;ESRP2;ESRP1;CPEB3;EIF4G3;SLC25A4;D1PAS1;RBM43 Electron Transport Chain WP295 3/103 0.9999958512468959 0.9999964152577399 0 0 0.10078659070990359 4.1813954843488335E-7 UCP3;UCP1;SLC25A4 Cytoplasmic Ribosomal Proteins WP163 1/92 0.9999960052480407 0.9999964152577399 0 0 0.03692365453206452 1.475011359032063E-7 RPL7 Oxidative phosphorylation WP1248 1/62 0.9999964152577399 0.9999964152577399 0 0 0.05519053876478318 1.9784421128065188E-7 NDUFA4L2